Detalhe da pesquisa
1.
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease.
Proc Natl Acad Sci U S A
; 119(40): e2210779119, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36161945
2.
Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
Blood
; 138(13): 1172-1181, 2021 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34197597
3.
Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.
Proc Natl Acad Sci U S A
; 117(26): 15018-15027, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527859
4.
MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding.
Biophys J
; 120(12): 2543-2551, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932439
5.
Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease.
Proc Natl Acad Sci U S A
; 114(5): E689-E696, 2017 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096387
6.
Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.
Bioconjug Chem
; 30(3): 568-571, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30794381
7.
Experimental basis for a new allosteric model for multisubunit proteins.
Proc Natl Acad Sci U S A
; 111(35): 12758-63, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139985
8.
Comparing a simple theoretical model for protein folding with all-atom molecular dynamics simulations.
Proc Natl Acad Sci U S A
; 110(44): 17880-5, 2013 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24128764
9.
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.
Biophys J
; 109(6): 1264-72, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26038112
10.
Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography.
Proc Natl Acad Sci U S A
; 109(47): 19256-61, 2012 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23132943
11.
Voxelotor treatment of a patient with sickle cell disease and very severe anemia.
Am J Hematol
; 94(4): E88-E90, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30592074
12.
Making connections between ultrafast protein folding kinetics and molecular dynamics simulations.
Proc Natl Acad Sci U S A
; 108(15): 6103-8, 2011 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21441105
13.
Tertiary and quaternary allostery in tetrameric hemoglobin from Scapharca inaequivalvis.
Biochemistry
; 52(12): 2108-17, 2013 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23458680
14.
Measuring internal friction of an ultrafast-folding protein.
Proc Natl Acad Sci U S A
; 105(47): 18320-5, 2008 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19020085
15.
Chemical, physical, and theoretical kinetics of an ultrafast folding protein.
Proc Natl Acad Sci U S A
; 105(48): 18655-62, 2008 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19033473
16.
Estimating free-energy barrier heights for an ultrafast folding protein from calorimetric and kinetic data.
J Phys Chem B
; 112(19): 5938-49, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18278894
17.
Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation.
J Phys Chem B
; 122(49): 11579-11590, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30179501
18.
Relaxation rate for an ultrafast folding protein is independent of chemical denaturant concentration.
J Am Chem Soc
; 129(47): 14564-5, 2007 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17983235
19.
A tertiary two-state allosteric model for hemoglobin.
Biophys Chem
; 98(1-2): 149-64, 2002 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12128196
20.
Evolution of allosteric models for hemoglobin.
IUBMB Life
; 59(8-9): 586-99, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17701554